Name:Miao Li

Position:Associated professor

Tel:87351875

Email:miaoli@yzu.edu.cn

Introduction:

Dr Miao's main research interests include "Screen for the bioactive strains from marine microbes, including quorum sensing inhibiting, antibacterial, antifungal, antitumor, antilarval activities", "Isolation, purification and identification of bioactive compounds from microbial extracts", and "Isolation, cultivation and identification of microorganisms from marine samples.

Dr Miao's has been in charged and completed 1 National Natural Science Fund project, 1 provincial and ministerial project, 7 municipal and department level projects, and participated in more than 10 other projects. She has published more than 30 papers, including 16 SCI papers, and also obtained 1 authorized national invention patent.

Education:

1995.9-1999.7 BSc, Microbiology, School of Life Science, Xiamen University,

1999.9-2002.7 Mphil, Microbiology, School of Life Science, Xiamen University

2002.8-2006.7 PhD, Biology, Coastal Marine Laboratory, Hong Kong University of Science and Technology

Achievements in scientific research:

Selected Research projects

1. "Screen and isolation of bacterial quorum sensing inhibitors from red sea microbes and their quantitative structure activity relationship study", National Natural Science Fund of China (No. 41006097, 2011.1-2013.12), in charge.

2. "Screen and isolation of antitumor substances from endophytic fungus and their quantitative structure activity relationship study", Opening Fund of the State Key Laboratory of Drug Research (No. SIMM1106KF-09, 2011.7-2012.6), in charge.

3. "Isolation and screen of anti-quorum sensing marine actinomycetes and bioactive substances" Key Laboratory of Marine Medicine, Guangdong Province and Key Laboratory of Tropical Marine Bio-resources and Ecology, Chinese Academy of Sciences (No.2018011008, 2018.1-2019.12), in charge.

4. "Screen and isolation of quorum sensing inhibitors from marine microbes", Natural Science Foundation for college and university of Jiangsu Province (No. 10KJB170013, 2011.1-2012.12), in charge.

5. "Study on the quorum sensing inhibitive activity and active substances from marine microorganisms". Key Laboratory of Marine Drug, Ministry of Education (No. KLMD(OUC)201203, 2012.1-2013.12), in charge.

6. "Study on the inhibitory role of QSI during the process of marine biofilm formation and induction to biofouling" (2013.12-2014.12), Scientific Innovation Training Project ofYangzhou University, in charge

Selected publications

1.Miao Li, Yang Jiafan, Jiang Wei, Zhou Huiru, Zhou Heng, Dong Kunming. Isolation and identification of antitumor active substance from an endophytic fungus Aspergillus oryzae YX-5 isolated from Ginkgo biloba. Microbiology China, 2019.46(4):842-849

2. Jiang Wei, Shan Tizhuang, Xu Jiajun, Chen Wen Ju,Miao Li, Lv Mengying, Tao Li, Liu Yanqing. Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus. Journal of Natural Medicines, 2019, 73: 841–846

3. Zhou Heng, Jiang Yun, Xu Yexiang, Qian Shenghui,Miao Li*. Research on quorum sensing inhibitory activity and culture condition of a marine Streptomyces parvulus. Biotechnology Bulletin, 2019.35(10):137-143

4.Miao Li, Xu Jie, Yao Ziwei, Jiang Yun, Zhou Huiru, Jiang Wei, Dong Kunming * The anti-quorum sensing activity and bioactive substance of a marine derived Streptomyces. Biotechnology and Biotechnological Equipment, 2017, 31(5): 1007-1015

5. Zhou Xiaojian, Meng Jie, Yu Zhaowei,Miao Li, Jin Cuili *. The alterations of biofilm formation and EPS characteristics of a diatom by a sponge-associated bacterium Psychrobacter sp. Scientifica. 2018, Article ID 1892520.

6.Miao Li, Wang Xueling, Jiang Wei, Yang Shengping、Zhou Huiru、Zhai Youpeng、Zhou Xiaojian、Dong Kunming*, Optimization of the culture condition for an antitumor bacterium Serratia proteamacula 657 and identification of the active compounds. World Journal of Microbiology and Biotechnology, 2013, 29(5), pp 855-863

7.Miao Li, Zhou Huiru, Ding Biting, Jiang Yun, Jiang Wei, Dong Kunming. Study on the anti-quorum sensing activity of a marine bacterium Staphylococcus saprophyticus 108. BioTechnology: An Indian Journal, 2013, 7(11):480-487

8. Zhou Huiru, Luan Haibin, Wang Hui, Dong Kunming,Miao Li*, Optimization of the fermentation medium of an antitumor endophytic fungus Aspergillus oryzae YX-5 isolated from Ginkgo biloba, Microbiology China, 2014, 41(7): 1358-1367

9. Zhai Youpeng, Zhou Huiru, Kong Kunming, Jiang Yun, Ding Biting,Miao Li*. The influence of quorum sensing inhibitors against marine functional bacterial biofilm formation. Microbiology China, 2013, 40(7): 1145-1153.

10. Lai PY,Miao L, Lee OO, Liu LL, Zhou XJ, Xu Y, Al-Suwailem A, Qian PY. Profundibacterium mesophilum gen. nov., sp. nov., a novel member in the family Rhodobacteraceae isolated from deep sea sediment in the Red Sea, Saudi Arabia. International Journal of Systematic and Evolutionary Microbiology, 2013, 63: 1007-1017.

11. Hui-xian Wu, Pok Yui Lai, On On Lee, Xiao-jian Zhou,Li Miao, Hao Wang and Pei-Yuan Qian. Erythrobacter pelagi sp. nov., a novel bacterium in the family Erythrobacteraceae isolated from the Red Sea. International Journal of Systematic and Evolutionary Microbiology, 2012, 62:1348-1353

12. Dong Kunming, Zhou Xiaojian, Jin Cuili,Miao Li*. Analysis of the inhibitory components from extracts of Magnalia grandiflora leaves against Microcystis Aeruginasa. 2011 International Conference on Ecological Protection of Lakes Wetlands Watershed and application of 3S, 2011.7, p32-35 (ISTP)

13.Miao Li, Dong Xiawei, Ding Biting, Zhou Xiaojian, Dong Kunming. Isolation and identification of biocontrol fungi against tobacco bacterial wilt and their antagonistic activity, Journal of Henan Agricultural Sciences, 2011, 40(11): 81-85.

14.Miao L, Dong KM, Li N, Zhou XJ, Jin CL, Feng K. Antialgal activities of allelochemical extracts from 3 terrestrial plant species. Agricultural Science & Technology, 2010,11(7): 20-24.

15. Qi SH,Miao L, Gao CH, Xu Y, Zhang S, Qian PY. New steroids and a new alkaloid from the gorgonian Isis minorbrachyblasta: structures, cytotoxicity, and antilarval Activity. Helvetica Chimica ACTA, 2010, 93: 511-516.

16.Miao Li, Wang Yuanyuan, Zhu Lei, Wu Zhengjun, Zhou Rumei. Endophytic fungi from four plant species: their isolation and antitumor activity. Microbiology China, 2009, 36: 865-869.

17. Xiong HR, Qi, SH, Xu Y,Miao L, Qian PY. Antibiotic and antifouling compound production by the marine-derived fungus Cladosporium sp. F14. Hydro-environment Research, 2009, 2:264-270.

18.Miao L, Kwong TFN, Qian PY. Effect of culture conditions on the mycelial growth, antibacterial activity and metabolite profiles of the marine-derived fungus Arthrinium c.f. saccharicola. Applied Microbiology and Biotechnology, 2006, 72: 1063-1073.

19.Miao L, Qian PY. Antagonistic antimicrobial activity of marine fungi and bacteria isolated from natural marine biofilm from Hong Kong waters. Aquatic Microbial Ecology, 2005, 38: 231-238.

20. Xu Y,Miao L, Li XC, Xiao X, Qian PY. Antibacterial and antilarval activity of deep-sea bacteria from sediments of West Pacific Ocean. Biofouling, 2007, 23:131-137.

21. Yang LH,Miao L, Lee OO, Li XC, Pang KL, Vrijmoed L, Qian PY. Effect of culture conditions on antifouling compound production of a sponge associated fungus. Applied Microbiology and Biotechnology. 2007, 74:1221-1231.

22. Kwong TFN,Miao L, Qian PY. Novel antifouling compound from a marine-derived fungus Ampelomyces sp. Marine Biotechnology, 2006, 8: 634-640.

Patent

Miao Li, Dong Kunming, Jiang Yun, Zhou Huiru, Zhai Youpeng, Zhou Xiaojian, A marine Streptomyces parvulus and its application in quorum sensing inhibition, 2015.08.26, China, ZL201310723024.5